616.234.5000

Publications

Shen Laboratory

Selected Publications

2017

The Cancer Genome Atlas Research Network. 2017. Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell. 169(7):1327–1341.   Article

Cherniack AD, Shen H…Laird PW…The Cancer Genome Atlas Research Network..Akbani R, Levine DA. 2017. Integrated molecular characterization of uterine carcinoma. Can Cell 31(3):411–423.      Article

2016

The Cancer Genome Atlas Research Network. 2016. Comprehensive molecular characterization of papillary renal-cell carcinoma. New Eng J Med 374(2):135–145.  Article

Gross AM, Jaeger PA, Kreisberg JF, Loncon K, Jepsen KL, Khosroheidari M, Morsey BM, Swindells S, Shen H, Ng CT, Flagg K, Chen D, Zhang K, Fox HS, Ideker T. 2016. Methylome-side analysis of chronic HIV infection reveals five-year increase in biological age and epigenetic targeting of HLA. Mol Cell 62(2):157–168. Article

Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Jiang P, Shen H, Aster JC, Rodig S, Signoretti S, Liu JS, Liu XS. 2016. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol 17:174.  PubMed

Liu M, Ohtani H, Zhou W, Ørskov AD, Charlet J, Zhang YW, Shen H, Baylin SB, Liang G, Grønbaek K, Jones PA.  2016. Vitamin C increases viral mimicry induced by 5-aza-2-deoxycytidine. Proc Natl Acad Sci USA 113(37):10238–10244.  Article

Rhie SK, Guo Y, Tak YG, Yao L, Shen H, Coetzee GA, Laird PW, Farnham PJ. 2016. Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits. Epigenetics Chromatin 9:50.  Article

Zhang X, Guo C, Wu X, Li AX, Liu L, Tsark W, Dammann R, Shen H, Vonderfecht SL, Pfeifer GP. 2016. Analysis of liver tumor–prone mouse models of the Hippo kinase scaffold proteins RASSF1A and SAV1. Cancer Res 76(9):2824–2935.  Article

2015

The Cancer Genome Atlas Research Network. 2015. The molecular taxonomy of primary prostate cancer.  Cell 163(4):1011–1025.   Article

Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GMK, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA, TCGA Research Network, Perou CM. 2015. Comprehensive molecular portraits of invasive lobular breast cancer. Cell 163(2):506–519.       Article

Yao L, Shen H, Laird PW, Farnham PJ, Berman BP. 2015. Inferring regulatory element landscapes and transcription factor networks from cancer methylomes. Genome Biol 16:105.    PubMed

Cancer Genome Atlas Research Network*. 2015. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas.  New Engl J Med 372(26):2481–2498.     PubMed
*Shen H is one of 328 co-authors

2014

Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, The Cancer Genome Atlas Research Network, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, and Creighton CJ. 2014. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell 26(3):319–330. PubMed

Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MD, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, Van’t Veer LJ, Lopez-Bigas N, Laird PW, Raphael BJ, Ding L, Robertson AG, Byers LA, Mills GB, Weinstein JN, Van Waes C, Chen Z, Collisson EA, The Cancer Genome Atlas Research Network, Benz CC, Perou CM, and Stuart JM. 2014. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 158(4):929–944. PubMed

Cancer Genome Atlas Research Network.* 2014. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513(7517):202–209. PubMed
*Shen H is one of 315 co-authors

The Cancer Genome Atlas Research Network.* 2014. Comprehensive molecular characterization of urothelial carcinoma of the bladder. Nature 507(7492): 315-322 PubMed       Article
*Shen H is a coauthor.

2013

Ari Hakimi A, Furberg H, Zabor EC, Jacobsen A, Schultz N, Ciriello G, Mikklineni N, Fiegoli B, Kim PH, Voss MH, Shen H, Laird PW, Sander C, Reuter VE, Motzer RJ, Hsieh JJ, Russo P. 2013. An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. Journal of the National Cancer Institute 105(24):1862-70. PubMed

Yoshihara K, Shahmoradgoli M, Martnez E, Vegesna R, Kim H, Torres-Garcia W, Trevino V, The Cancer Genome Atlas Research Network, Shen H, Laird PW, Levine DA, Carter SL, Getz G, Stemke-Hale K, Mills GB, Verhaak RGW. 2013. Estimating the presence of tumor-associated normal cells using gene expression signatures predicts tumor purity. Nature Communications 4:2612.

Zack TI, Schumacher SE, Carter SL, Cherniack AD, Saksena G, Tabak B, Lawrence MS, Zhang CZ, Wala J, Hermel CH, Sougnez C, Gabriel SB, Hernandez B, Shen H, Laird PW, Getz G, Meyerson M, Beroukhim R. 2013. Pan-cancer patterns of somatic copy number alteration. Nature Genetics 45(10):1134-1140. PubMed

Cancer Genome Atlas Research Network; Genome Characterization Center, Chang K, Creighton CJ, Davis C, Donehower L, Drummond J, Wheeler D, Ally A, Balasundaram M, Birol I, Butterfield YS, Chu A, Chuah E, Chun HJ, Dhalla N, Guin R, Hirst M, Hirst C, Holt RA, Jones SJ, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall AJ, Robertson AG, Schein JE, Sipahimalani P, Tam A, Thiessen N, Varhol RJ, Beroukhim R, Bhatt AS, Brooks AN, Cherniack AD, Freeman SS, Gabriel SB, Helman E, Jung J, Meyerson M, Ojesina AI, Pedamallu CS, Saksena G, Schumacher SE, Tabak B, Zack T, Lander ES, Bristow CA, Hadjipanayis A, Haseley P, Kucherlapati R, Lee S, Lee E, Luquette LJ, Mahadeshwar HS, Pantazi A, Parfenov M, Park PJ, Protopopov A, Ren X, Santoso N, Seidman J, Seth S, Song X, Tang J, Xi R, Xu AW, Yang L, Zeng D, Auman JT, Balu S, Buda E, Fan C, Hoadley KA, Jones CD, Meng S, Mieczkowski PA, Parker JS, Perou CM, Roach J, Shi Y, Silva GO, Tan D, Veluvolu U, Waring S, Wilkerson MD, Wu J, Zhao W, Bodenheimer T, Hayes DN, Hoyle AP, Jeffreys SR, Mose LE, Simons JV, Soloway MG, Baylin SB, Berman BP, Bootwalla MS, Danilova L, Herman JG, Hinoue T, Laird PW, Rhie SK, Shen H, Triche T, Weisenberger DJ, Carter SL, Cibulskis K, Chin L, Zhang J, Getz G, Sougnez C, Wang M; Genome Data Analysis Center, Saksena G, Carter SL, Cibulskis K, Chin L, Zhang J, Getz G, Dinh H, Doddapaneni HV, Gibbs R, Gunaratne P, Han Y, Kalra D, Kovar C, Lewis L, Morgan M, Morton D, Muzny D, Reid J, Xi L, Cho J, Dicara D, Frazer S, Gehlenborg N, Heiman DI, Kim J, Lawrence MS, Lin P, Liu Y, Noble MS, Stojanov P, Voet D, Zhang H, Zou L, Stewart C, Bernard B, Bressler R, Eakin A, Iype L, Knijnenburg T, Kramer R, Kreisberg R, Leinonen K, Lin J, Liu Y, Miller M, Reynolds SM, Rovira H, Shmulevich I, Thorsson V, Yang D, Zhang W, Amin S, Wu CJ, Wu CC, Akbani R, Aldape K, Baggerly KA, Broom B, Casasent TD, Cleland J, Creighton C, Dodda D, Edgerton M, Han L, Herbrich SM, Ju Z, Kim H, Lerner S, Li J, Liang H, Liu W, Lorenzi PL, Lu Y, Melott J, Mills GB, Nguyen L, Su X, Verhaak R, Wang W, Weinstein JN, Wong A, Yang Y, Yao J, Yao R, Yoshihara K, Yuan Y, Yung AK, Zhang N, Zheng S, Ryan M, Kane DW, Aksoy BA, Ciriello G, Dresdner G, Gao J, Gross B, Jacobsen A, Kahles A, Ladanyi M, Lee W, Lehmann KV, Miller ML, Ramirez R, Rtsch G, Reva B, Sander C, Schultz N, Senbabaoglu Y, Shen R, Sinha R, Sumer SO, Sun Y, Taylor BS, Weinhold N, Fei S, Spellman P, Benz C, Carlin D, Cline M, Craft B, Ellrott K, Goldman M, Haussler D, Ma S, Ng S, Paull E, Radenbaugh A, Salama S, Sokolov A, Stuart JM, Swatloski T, Uzunangelov V, Waltman P, Yau C, Zhu J, Hamilton SR; Sequencing Center, Getz G, Sougnez C, Abbott S, Abbott R, Dees ND, Delehaunty K, Ding L, Dooling DJ, Eldred JM, Fronick CC, Fulton R, Fulton LL, Kalicki-Veizer J, Kanchi KL, Kandoth C, Koboldt DC, Larson DE, Ley TJ, Lin L, Lu C, Magrini VJ, Mardis ER, McLellan MD, McMichael JF, Miller CA, O’Laughlin M, Pohl C, Schmidt H, Smith SM, Walker J, Wallis JW, Wendl MC, Wilson RK, Wylie T, Zhang Q; Data Coordinating Center, Burton R, Jensen MA, Kahn A, Pihl T, Pot D, Wan Y; Tissue Source Site, Levine DA; Biospecimen Core Resource Center, Black AD, Bowen J, Frick J, Gastier- Foster JM, Harper HA, Helsel C, Leraas KM, Lichtenberg TM, McAllister C, Ramirez NC, Sharpe S, Wise L, Zmuda E; National Cancer Institute/National Human Genome Research Institute Project Team, Chanock SJ, Davidsen T, Demchok JA, Eley G, Felau I, Ozenberger BA, Sheth M, Sofia H, Staudt L, Tarnuzzer R, Wang Z, Yang L, Zhang J; Collaborators, Omberg L, Margolin A, Raphael BJ, Vandin F, Wu HT, Leiserson MD, Benz SC, Vaske CJ, Noushmehr H, Knijnenburg T, Wolf D, Veer LV, Collisson EA, Anastassiou D, Ou Yang TH, Lopez-Bigas N, Gonzalez-Perez A, Tamborero D, Xia Z, Li W, Cho DY, Przytycka T, Hamilton M, McGuire S, Nelander S, Johansson P, Jrnsten R, Kling T, Sanchez J,Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. 2013. The Cancer Genome Atlas Pan-Cancer analysis project. Nature Genetics 45(10):1113-20. PubMed       Article

Cheng WY, Ou Yang TH, Shen H, Laird PW, Anastassiou D, The Cancer Genome Atlas Research Network. 2013. Multi-cancer molecular signatures and their interrelationships. arXiv:1306.2584 Article

The Cancer Genome Atlas Research Network.* 2013. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499(7456):43-9. *Shen H is a coauthor and led DNA methylation analysis. PubMed

The Cancer Genome Atlas Research Network.* 2013. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. New England Journal of Medicine 368(22):2059-74. PubMed
*Shen H is a coauthor.

The Cancer Genome Atlas Research Network, Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, Yau C, Laird PW, Ding L, Zhang W, Mills GB, Kucherlapati R, Mardis ER, Levine DA. 2013. Integrated genomic characterization of endometrial carcinoma. Nature 497(7447):67-73. PubMed

Shen H, Laird PW. 2013. Interplay between the cancer genome and epigenome. Cell 153(1):38-55. Article

Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H,Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E; Australian Cancer Study; Australian Ovarian Cancer Study Group, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM, Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, Drk T, du Bois A, Drst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, Hgdall E, Hgdall CK, Hosono S, Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J, Lubiski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA, Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shen H, Shridhar V, Shu XO, SiehW, Southey MC, Spellman P, Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS, van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B, Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT, Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro AN, Gayther SA, Schildkraut JM, Sellers TA. 2013. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nature Genetics 45(4):362-70. PubMed         Article

Shen H, Fridley BL, Song H, Lawrenson K, Cunningham JM, Ramus SJ, Cicek MS, Tyrer J, Stram D, Larson MC, Kbel M; PRACTICAL Consortium, Ziogas A, Zheng W, Yang HP, Wu AH, Wozniak EL, Ling Woo Y, Winterhoff B, Wik E, Whittemore AS, Wentzensen N, Palmieri Weber R, Vitonis AF, Vincent D, Vierkant RA, Vergote I, Van Den Berg D, Van Altena AM, Tworoger SS, Thompson PJ, Tessier DC, Terry KL, Teo SH, Templeman C, Stram DO, Southey MC, Sieh W, Siddiqui N, Shvetsov YB, Shu XO, Shridhar V, Wang- Gohrke S, Severi G, Schwaab I, Salvesen HB, Rzepecka IK, Runnebaum IB, Anne Rossing M, Rodriguez-Rodriguez L, Risch HA, Renner SP, Poole EM, Pike MC, Phelan CM, Pelttari LM, Pejovic T, Paul J, Orlow I, Zawiah Omar S, Olson SH, Odunsi K, Nickels S, Nevanlinna H, Ness RB, Narod SA, Nakanishi T, Moysich KB, Monteiro AN, Moes-Sosnowska J, Modugno F, Menon U, McLaughlin JR, McGuire V, Matsuo K, Mat Adenan NA, Massuger LF, Lurie G, Lundvall L, Lubiski J, Lissowska J, Levine DA, Leminen A, Lee AW, Le ND, Lambrechts S, Lambrechts D, Kupryjanczyk J, Krakstad C, Konecny GE, Krger Kjaer S, Kiemeney LA, Kelemen LE, Keeney GL, Karlan BY, Karevan R, Kalli KR, Kajiyama H, Ji BT, Jensen A, Jakubowska A, Iversen E, Hosono S, Hgdall CK, Hgdall E, Hoatlin M, Hillemanns P, Heitz F, Hein R, Harter P, Halle MK, Hall P, Gronwald J, Gore M, Goodman MT, Giles GG, Gentry- Maharaj A, Garcia-Closas M, Flanagan JM, Fasching PA, Ekici AB, Edwards R, Eccles D, Easton DF, Drst M, du Bois A, Drk T, Doherty JA, Despierre E, Dansonka-Mieszkowska A, Cybulski C, Cramer DW, Cook LS, Chen X, Charbonneau B, Chang-Claude J, Campbell I, Butzow R, Bunker CH, Brueggmann D, Brown R, Brooks-Wilson A, Brinton LA, Bogdanova N, Block MS, Benjamin E, Beesley J, Beckmann MW, Bandera EV, Baglietto L, Bacot F, Armasu SM, Antonenkova N, Anton-Culver H, Aben KK, Liang D, Wu X, Lu K, Hildebrandt MA; stralian Ovarian Cancer Study Group; Australian Cancer Study, Schildkraut JM, Sellers TA, Huntsman D, Berchuck A, Chenevix-Trench G, Gayther SA, Pharoah PD, Laird PW, Goode EL, Leigh Pearce C. 2013. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nature Communications 4:1628. PubMed

2012

Lange CP, Campan M, Hinoue T, Schmitz RF, van der Meulen-de Jong AE, Slingerland H, Kok PJ, van Dijk CM, Weisenberger DJ, Shen H, Tollenaar RA, Laird PW. 2012. Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS One 7(11):e50266. PubMed

The Cancer Genome Atlas Network.* 2012. Comprehensive molecular portraits of human breast tumors. Nature 490(7418):61-70. PubMed
*Shen H is a coauthor.

Zhang S, Liu CC, Li W, Shen H, Laird PW, Zhou XJ. 2012. Discovery of multi-dimensional modules by integrative analysis of cancer genomic data. Nucleic Acids Research 40(19):9379-91. PubMed           Article

The Cancer Genome Atlas Network.* 2012. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330-7. PubMed
*Shen H is a coauthor.

Carter SL, Cibulskis K*, Helman E*, McKenna A*, Shen H*, Zack T*, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G. 2012. Absolute quantification of somatic DNA alterations in human cancer. Nature Biotechnology 30(5):413-21. PubMed       Article
*These authors contributed equally to the work.

Shen H, Laird PW. 2012. In epigenetic therapy, less is more. Cell Stem Cell 10(4):353-4. Article

2011

Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW. 2011. Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. PLoS One 29(12):1132-44. PubMed      Article

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. 2011. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nature Biotechnology 29(12):1132-44.              PubMed       Article

Hinoue T, Weisenberger DJ, Lange CP, Shen H, Byun HM, Van Den Berg D, Malik S, Pan F, Noushmehr H, van Dijk CM, Tollenaar RA, Laird PW. 2012. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Research 22(2):271-82. PubMed      Article

The Cancer Genome Atlas Research Network. 2011. Integrated genomic analyses of ovarian carcinoma. Nature 474(7353):609-15. PubMed
*Shen H is a coauthor and led the DNA methylation analysis.

Oghamian S, Sodir NM, Bashir MU, Shen H, Cullins AE, Carroll CA, Kundu P, Shibata D, Laird PW. 2011. Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis 32(6):829-35. PubMed      Article

Noushmehr H,Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K; Cancer Genome Atlas Research Network. 2010. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17(5):510-22. PubMed           Article

Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, Savage DA, Mueller-Holzner E, Marth C, Kocjan G, Gayther SA, Jones A, Beck S, Wagner W, Laird PW, Jacobs IJ, Widschwendter M. 2010. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Research 20(4):440-6. PubMed           Article